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In addition, pathogenic microorganisms can influence the homeostatic imbalance of the intestinal flora, thereby affecting the immune system and damaging the mesenteric mucosal barrier, promoting joint damage in RA (Maeda et al., 2016)

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However, prolonged gastric retention also means delayed arrival at the intrinsic factor binding sites and the ileal absorption receptors

In a 14-month randomized, double-blind, placebo-controlled trial that administered a daily micronutrient-fortified beverage (details lacking) or placebo to 608 children (aged 6-15 years) in India, micronutrient supplementation was linked to improved scores on one measure of attention and concentration (Knox Cube test) but not on another assessment (Letter Cancellation test) (104)