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However, the half-life in the bloodstream is extremely short, so for optimal effects, very frequent administration is needed, and the efficacy is unproven

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Mller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn P-H (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

This study hypothesizes that significant decreases in three key indicatorsrespiratory quotient, heart rate, and subjective perception of exertion would indicate that the experimental L-carnitine (LC) supplementation protocol reduces exercise load and enhances endurance limits more effectively than the classical supplementation strategy