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Abstract Adverse pregnancy consequences such as preeclampsia, diabetes and gestational hypertension can contribute to maternal vascular cognitive impairment and dementia (VCID) risk via vascular endothelial dysfunction and neuroinflammation, resulting in progressive cognitive health decline

In addition, some investigators found that USP22 and lncRNA PART1 expression was decreased in a MIR injury model

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However, off-target effects still cause the risk of normal cell damage and serious side effects