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Growth Factor Pathway Modulation Beyond VEGF, BPC-157 has been documented to influence the expression or activity of several growth factors and signaling intermediates relevant to tissue organization: EGF receptor (EGFR): BPC-157 has been shown to upregulate EGFR-dependent signaling in gastrointestinal epithelial models, consistent with its gastroprotective effects (Sikiric et al., 2016, Current Neuropharmacology

This has a direct impact on its behavior in aqueous solutions and buffers

This modification, designed to increase duration of action, also extends the detection window

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