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The GWAS data for the 1400 metabolites were obtained from Chen et al.11 Abbreviations NAFLD: Non-Alcoholic Fatty Liver Disease GWAS: Genome-Wide Association Study FDR: False Discovery Rate LDSC: Linkage Unbalanced Regression cML-MA: Constrained Maximum Likelihood and Model Averaging OR: Odds Ratio HCC: Hepatocellular Carcinoma MR: Mendelian Randomization IVs: Instrumental Variables rRNA: Ribosomal Ribonucleic Acid IEU: Integrative Epidemiology Unit SNPs: Single Nucleotide Polymorphisms SE: Standard Error WM: Weighted Median IVW: Inverse Variance Weighted FMT: Fecal Microbiota Transplantation LDL: Low-Density Lipoprotein References Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, et al

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Additional, supplementation of sodium pyruvate and JX06 in GGCT-knockdown cells confirmed that this regulatory effect of GGCT-mediated changes in ROS was independent of energy metabolism pathways

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