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Medical authorities state that less than 1.5ml can be given comfortably and anything greater than 2ml causes pressure on the surrounding tissues causing pain

1998 Oct;46(5):194-6

Antibiotic and nonantibiotic drugs associated with Clostridioides difficile infection risk: a pharmacopoeia-wide case-cohort study

Animal models exposed to 5-Amino-1MQ demonstrate accelerated lipid metabolism and extensive white adipose tissue remodelling, driven by up-regulated SIRT1 activity