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Mean enrichment scores of gene expression within grouped excitatory and inhibitory neuron classes were calculated and plotted against mean proteoform coefficients from the continuous linear models (Fig

RNU6-1 is a small nuclear RNA commonly used as an internal control due to its stable expression across different sample conditions, which ensures consistency and reliability in the measurement of target gene expression

Crucially, the ROS generated during GSH degradation by CHAC1 may also cause further TP53 mutations, creating a vicious self-reinforcing cycle: CHAC1 activity promotes the very TP53 mutations that allow the tumor to exploit CHAC1s harmful effect for growth

Age was also found to be a borderline significant factor (OR: 0.95, 95% CI: 0.891.01, P = 0.05), with younger patients tending to show greater improvement in fibrosis markers and grades