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This can occur due to conditions such as pernicious anemia, gastrointestinal disorders like Crohns disease, or following gastrointestinal surgery

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It is modified with: An arginine substitution at position 3 (hence Arg3) An extended amino acid chain that lengthens its half-life from a matter of minutes to around 2030 hours This modification prevents IGF-1 LR3 from binding to IGF-binding proteins (IGFBPs) as readily, allowing it to remain active in the bloodstream longer and exert more potent effects

I think a lot of it is dogma and confusion