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Cysteine is the most important amino acid, but B-vitamins (B6, B12, folate) are essential cofactors

Selenium plays an important role in regulating thyroid hormone metabolism and may improve the function of the thyroid gland in subclinical hypothyroidism by promoting better conversion of T4 to the active form T3 [23]

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Sublingual preparations are available, though evidence for their superiority over standard oral tablets is limited, and they are not routinely recommended in UK clinical practice