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Decreased levels of TNF- and IL-6 indicate that NNMT inhibition not only modulates metabolism but also improves the inflammatory microenvironment, a key component in metabolic disease development and insulin resistance

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However, to measure BBB permeability, the movement of GBCAs from blood to the extravascular space must be tracked

View on PubMed Contributions by the Brain Renin-Angiotensin System to Memory, Cognition, and Alzheimer's Disease Reviewed the role of brain angiotensin signalling in learning, memory, and neurodegeneration, providing mechanistic context for angiotensin IV analog therapies including Dihexa (J Alzheimers Dis, 2019)