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Similarly, tobacco exposure also resulted in a significantly higher mRNA expression of PARP, a marker of DNA damage and indicator of apoptosis, 43, 44 suggesting that the more extensive MI in tobacco-exposed rats is also accompanied by an increase in cardiomyocyte apoptosis

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Symptoms that may appear with withdrawal syndrome include slowed heart rate, lowered blood pressure, decreased levels of cortisol, decreased adrenaline levels, or lowered dopamine as the happiness hormone