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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the cytosolic enzyme that methylates nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosyl-L-methionine (SAM) as the methyl donor

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Secretary Kennedy has made no secret of his support for the molecules, saying he has used some of them himself and would like the FDA which is overseen by the Department of Health and Human Services to allow compounding pharmacies to again offer the drugs