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These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane

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This includes both NHS GPs and appropriately qualified private clinicians registered with the General Medical Council (GMC)

Formats and tolerance Oral presentations (capsules, tablets or liquids) are usually well tolerated , although digestive discomfort or a characteristic body odour may occur in some people