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Studies confirmed that the GSTM1 (null) polymorphism correlates with both dry and wet AMD stages [100]

Among the genes downregulated in response to GSTO1 siRNA, coagulation factor III ( F3 ), thrombospondin 1 ( THBS1 ), cysteine-rich angiogenic inducer ( CYR61 ) and bone morphogenetic protein 4 ( BMP4 ), related to blood coagulation and blood vessel morphogenesis, were markedly decreased (Supplementary Table 11)