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Elevated insulin levels cause an increase in insulin-like growth factor (IGF-1) and a decrease in insulin-like growth factor-binding protein 3 (IGFBP-3) (182)

See a dermatologist if you notice light-brown-to-black patches on your skin, especially if they appear suddenly

Inform your healthcare provider about all supplements and medicines you are taking so they can advise you about possible interactions

In addition to acute medicine use (see: Prescribe a NSAID, corticosteroid or colchicine to treat gout flares), encourage rest and elevation of the affected joint, adequate hydration, and some patients may find an ice pack beneficial