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OR: 1.11, 95% CI: 0.971.28, P = 0.128) and lower risk of high WHtR (OR: 0.83, 95% CI: 0.720.97, P = 0.01)

The complexity of neurosteroid-mediated effects, for instance gating of GABA A R (109, 135139) and subunit-specific modulation of glycine and NMDARs (140), suggest the likelihood of multiple binding sites that contribute to potentiating and inhibitory effects ( A Rs also appears to involve modulation of subunit-containing receptors which play a role in tonic inhibition (141145)

Metabolic health & insulin sensitivity Investigated in animal research on glucose handling and insulin sensitivity via AMPK activation