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2016;167(3):843-857.e814

These include CTLA-4 mediated interference with antigen-presenting cell function to limit costimulatory signals [113], the secretion of anti-inflammatory cytokines that directly inhibit Th2 and Th17 proliferation and effector functions, and the constitutive expression of high CD25 levels, enabling competitive consumption of IL-2 and the restriction of effector T-cell expansion [114]

In patients receiving multiple transplants, and who are on cyclosporine, rifampicin cannot be used as it reduces the concentration of cyclosporine very substantially as a result of hepatic enzyme induction

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