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In a study by Benkoucha et al., HGF exerted an anti-inflammatory effect through the generation of tolerogenic dendritic cells with the consequent suppression of auto-reactive T helper cells 1 (Th1) and Th17 cells and leading to the reduction of CD4 + T-cell-mediated nervous system injury in the experimental autoimmune encephalomyelitis (EAE) animal model of MS, in which HGF was overexpressed (HGF transgenic mice) (Benkhoucha et al., 2010)

[DOI] [PubMed] [Google Scholar] 47.Marconi S., Castiglione G., Turano E., Bissolotti G., Angiari S., Farinazzo A.Bonetti B

This peptide is naturally produced in the small intestine when we eat