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In addition, researchers have proposed lactate oxidase (LOx) as a therapeutic strategy to lower lactate levels, generate HO, and recruit immune cells, thereby overcoming immunosuppression and enhancing immunotherapy responsiveness [375, 376]

Furthermore, alterations in the gut microbiome can impact the effectiveness of cancer therapies, highlighting the potential of microbiome modulation as a therapeutic strategy

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It stimulates collagen production in dermal fibroblasts by up to 70% at optimal concentrations around 1 nanomolar