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That said, the clinical evidence in healthy populations is limited

This creates a fundamental design trade-off: optimizing for superior tissue penetration often comes at the cost of plasma persistence, and vice versa

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Dunn, [email protected] This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers