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Contrary to normal smokers, COPD patients have defects in DNA repair, as documented by very low expression of the double-stranded repair protein Ku86 (Caramori et al

Together, compensatory biceps-dominant activation and chronic supraspinatus unloading provide a mechanistic link between rotator cuff injury and sustained mitochondrial reactive oxygen species elevation, thereby facilitating activation of proteolytic and atrophy-related signaling pathways that drive progressive muscle degeneration

Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, et al

What exactly is it and what makes it important to our health