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Some studies indicate that DSIP may influence endogenous opioid signaling, although its effects are not consistently reversed by opioid antagonists, suggesting indirect modulation rather than direct receptor agonism [9]

The research utilized male Sprague-Dawley rats and various in vitro and ex vivo experimental models [1]

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GHK-Cu's role as a carrier peptide means it's less about direct messaging and more about providing a fundamental building block (copper) that the body then uses for its regenerative processes