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van Ommen B, den Besten C, Rutten AL, Ploemen JH, Vos RM, Muller F, van Bladeren PJ: Active site-directed irreversible inhibition of glutathione S-transferases by the glutathione conjugate of tetrachloro-1,4-benzoquinone

R For patients with GST null genotypes, aggressive support of glutathione status ( NAC , liposomal glutathione , sulforaphane for NRF2 induction of remaining GST isoforms) is essential

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Targets aging biology at the chromosomal level: Unlike hormonal peptides that act on membrane receptors, Epithalon operates at the genomic regulation level