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289 Additionally, as sentinel cells in the central nervous system, microglia upregulate the expression of insulin-like growth factor-binding protein 6 (IGFBP6) in response to lactate, thereby promoting M2 polarization and recruitment of microglia in the zebrafish GBM model

*Correspondence: Juan Du, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers