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A distinct nonclassical inflammasome pathway is triggered by direct binding of lipopolysaccharide (LPS) to caspase 11 (CASP11 in humans) or caspase 4/5 (CASP4/5 in mice), resulting in GSDMD cleavage [139]

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Maintaining an optimal level of glutathione appears to be important for supporting cognitive function, especially during aging.* The normal process of aging is associated with a decrease in glutathione activity, which can result in increased oxidative activity.* Less than optimum levels of glutathione are observed in individuals experiencing a decline in cognitive function.* Conversely, individuals living over 100 years tend to have higher glutathione activity.*