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Notably, oxidative phosphorylation efficiency at complexes I and IIspecifically when glucose was the fuel sourceemerged as a stronger predictor of GWS severity than markers of peripheral inflammation

The robust presence of innate immune elements at the leading edges led some to conclude that in these chronic active MS lesions, there is a switch with the innate rather than the adaptive immune system taking over to propagate the pathology (Weiner, 2008)