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Notably, in a phase III clinical trial, ES combined with paclitaxel showed limited success overall but demonstrated enhanced efficacy in melanoma patients with lower LDH levels (O'Day et al., 2013), suggesting that mitochondrial metabolism plays a pivotal role in cuproptosis activation

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Perumalsamy H, Xiao X, Kim H-Y, Yoon T-H

Immediate effect (day 3): Whereas the controls exhibited an increasing disappearance of arcade vessels, particularly at the dorsal side of the colon (Figures 9, 13 and 14), after BPC 157 bath treatment the arcade vessels vigorously reappeared together with interconnected collaterals between arcades, in particular, quickly rescuing blood flow (a finding especially seen at the dorsal side of the colon) (Figures 18, 21 and 22)