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500 Overexpression of GPX4 in mitochondria protects streptozotocin-induced heart damage

Implications & Mechanisms The fact that Reta slowed tumor growth without causing weight loss suggests it may act through: Direct effects on tumor cells and/or Modulation of immune responses or metabolism inside the tumor microenvironment

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A Transwell system (mimics the physiological barrier between two cellular compartments) was utilized to evaluate the permeability across BBB in an in vitro model utilizing brain capillary endothelial cells (BCECs)