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98 Melatonin is thought to reduce tinnitus by protecting hair cells (sensory cells in the ear responsible for hearing) from oxidative damage, promoting normal blood flow to inner ear structures, relaxing ear muscles, attenuating depression and anxiety, inhibiting the stress response, and supporting normal sleep patterns

In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau