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In particular, the efficacy in decreasing the recurrent episodes of UTIs was similar among the groups treated with nitrofurantoin or D-mannose [18]

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Although useful for studies of protein-mediated transport, for helping describe the contributions of specific proteins toward transcellular and paracellular solute and ion transport, and for high-throughput drug screening, [77, 78] extrapolation of data supporting the transport of microorganisms or large lipophilic molecules from cultured cells to the intact epithelium is at best hazardous

Mechanistically, LPS not only triggers macrophage pyroptosis but also promotes apoptosis and disrupts estrogen synthesis in granulosa cells (57)