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The gain of methylation was 20 times more frequent and it occurred on promoters of germline-specific and pluripotency genes, including Nanog and Oct4

Materials and methods This study aims to analyze the vascular function and aging status of the aorta in naturally aged mice and progeroid model mice following FOXO4-DRI injection

Immediate receptor binding (seconds to minutes), intracellular signaling cascade propagation (minutes to hours), gene expression changes (hours to days), protein synthesis and accumulation (days to weeks), cellular and tissue-level effects (weeks to months)

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