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5) Overtraining and false confidence This is not a pharmacologic side effect

It is well acknowledged that hypertension is the most critical risk factor for the development of CVD ( 2 O 2 generation, decreased nitric oxide synthesis, and impaired antioxidant bioavailability have all been associated with human hypertension ( 6.3

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Moreover, DAG extracted from Sargentodoxa cuneate exerts its antioxidant effect by upregulating GPX4 expression and downregulating phosphoextracellular regulated protein kinases and HO-1 expression to counteract APAP-induced ferroptosis in hepatocytes (Liu et al., 2022)