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Colony replating assay After performing the clonogenic assay as indicated above, cells in the colonies ( n = 3 plates for each condition) were de-attached, and the viable cells were counted, showing similar and representative reductions on absolute viable cell counts (GUAVA easycyte) as previously observed in the number of colonies (Supplementary Fig

respiratory syncytial virus-targeting mAb IgG1 nirsevimab [Beyfortus] [107] and severe acute respiratory syndrome coronavirus 2-targeting mix of the IgG1 mAbs tixagevimab cilgavimab [Evusheld] [108, 109]) and blocking activation of the complement cascade to treat the autoimmune disease paroxysmal nocturnal hemoglobinuria (anti-C5 IgG2/4 mAb ravulizumab [Ultomiris] containing the amino acid substitutions M428L/N434S (commonly referred to as LS)) [110]

Additionally, advanced lipid peroxidation end products can lead to oxidative damage to proteins or nucleic acids, causing cellular dysfunction [8]