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In mice, knockout of ChREBP has been shown to reduce hepatic fatty acid synthesis by 65% compared to wild-type controls, but also to promote insulin resistance, delayed glucose clearance, and severe intolerance to simple carbohydrates, such as sucrose and fructose (resulting in death in the majority of animals) due to an inability to shunt fructose into glycolytic pathways [48]

Fluoride 38(4):318323 Wang J, Niu R, Sun Z, Lv LH, Smith GW, Wang JD (2008) Effects of protein and calcium supplementation on bone metabolism and thyroid function in protein and calcium deficient rabbits exposed to fluoride

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Plant alkaloids are also recognized for their diuretic properties, particularly those containing benzyl isoquinoline-type alkaloids (47)