This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier
To view a copy of this licence, visit About this article Cite this article Siatka, T., Mtu, M., Moravcov, M
The published data on how adults feel about needles is unambiguous: 2% of adults experience needle phobia, according to a 2022 international study of 2,098 adults published in PLOS ONE
We thank the Butterworth and Jafarnejad labs at QUB for providing the U2OS cells and Torin1 compound, respectively