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Accordingly, agents that restore glutathione-glutamate homeostasis may afford therapeutic benefit

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Consequently, it is imperative to initiate pharmacological treatment in elderly patients with the lowest effective dose, with the possibility of gradually titrating the dosage upwards as deemed necessary (Zhou et al., 2008b)

We noticed, however, that the bottom part of subpocket C in the vicinity of the fragments found in the X-ray structures is formed by the hydrophobic portions of D325, Y479, A481, H538, G483, V469, T471 and is likely to prefer bulky hydrophobic substituents