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Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC

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However, no single genetic variation has been found to increase the risk of MDD thus far

both required TfRs, and both iron uptake processes required Tf ( in vivo ( Another overlooked feature of the hemeHPX cell interaction is the activation of signaling cascades, including the N-terminal cJun-kinase (JNK) pathway ( Furthermore, with respect to apo-HPX recycling in the context of HPX binding to a surface receptor, we consider that heparin binding to apo-HPX, but not hemeHPX, models an interaction between hemeHPX with an HPX receptor-associated surface HSPG, as suggested for holo-Tf and TfR1 ( It is not well recognized that plasma heme levels regulate the turnover of HPX ( i.e