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This study identified the machinery required to remove NEDD8 from cullins and demonstrated an important role for NEDD8-removal for the biological activity of SCF complexes

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Sulfamethoxazole is metabolized in humans to at least 5 metabolites: the N 4-acetyl-, N 4-hydroxy-, 5-methylhydroxy-, N 4-acetyl-5-methylhydroxy- sulfamethoxazole metabolites, and an N-glucuronide conjugate

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5 mg protocol (8 weeks, 8 vials): 24 mL 3 10 mL bottles 10 mg protocol (8 weeks, 4 vials): 12 mL 2 10 mL bottles 10 mg protocol (12 weeks, 7 vials): 21 mL 3 10 mL bottles Alcohol Swabs One for the vial stopper + one for the injection site each day

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