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The accumulation of reactive oxygen species (ROS), a hallmark of oxidative stress, serves a key role in initiating ferroptosis

A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathy

But the highest concentration of glutathione is found in the liver, making it critically important in the detoxification and elimination of free radicals

Collectively, these data demonstrated that 2012.2 are ser/gly synthesis-dependent GBM cells, highlighted by increased serine- and glycine-derived synthesis of nucleotides and GSH, as well as adaptive upregulation of PSPH under hypoxic conditions, which could be efficiently targeted by sertraline treatment