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a 2025 literature review identified limited clinical evidence, including a retrospective study of 12 patients with knee pain and a Phase I trial in healthy volunteers whose results were not submitted

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If a severe allergic reaction does occur, it will usually be within 20 - 30 minutes of giving the injection and the most common sign is collapse

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There is no good evidence for a B12 'detox' or 'toxin release', so treat that framing with caution

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