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Human embryonic stem cell-derived MSCs can also treat CTX-induced POF mice, potentially through paracrine mechanisms that involve the secretion of VEGF, IGF-2, and hepatocyte growth factor which help improve ovarian function, reduce granulosa cell apoptosis, and restore fertility [129]
Free Radic Biol Med 25:287297 Lopez-Lluch G, Hunt N, Jones B, Zhu M, Jamieson H, Hilmer S, Cascajo MV, Allard J, Ingram DK, Navas P, de Cabo R (2006) Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
Magnesium matters Leafy greens, pumpkin seeds, and high-quality magnesium supplements support cellular function and nervous system calm
Dietary strategies emphasizing low-GI, low-carbohydrate, and nutrient-dense foods can significantly alleviate metabolic and reproductive dysfunctions associated with this condition
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