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Long-term use of NSAIDs can lead to impaired glomerular filtration, renal tubular necrosis, and ultimately chronic renal failure by disrupting prostaglandin synthesis, which can impair renal blood flow (Weir 2002)

This means your body has to rebuild the molecule from scratch, which is an inefficient process especially if your system is already under oxidative pressure

After completing a cycle, take at least 4 weeks off before starting another cycle to prevent receptor downregulation

Also, if youre using a laminar flow hood or clean bench, sterilize the workspace with appropriate disinfectant (and UV light, if available, prior to work)