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Injectable vitamin B12 may be considered to deliver the nutrient directly for cellular use

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The peptide diffuses laterally through interstitial fluid before entering systemic circulation, meaning a significant fraction reaches dermal fibroblasts at concentrations 35 higher than what systemic distribution via IM would achieve

Since the 1990s, pollution has worsened in almost every river in Africa, Asia and Latin America, and it is expected to deteriorate further in the coming two decades, mainly due to agriculture runoffs of fertiliser and other agrochemicals that load freshwater supplies with nutrients that lead to the growth of pathogens and choking algae blooms