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DOI: 10.1038/288715a0 PMID: 7453802 Maquart FX, Pickart L, Laurent M, et al

The use of e-cigarettes can also impair male reproductive health as it can disturb the hypothalamo-pituitary axis, increase DNA fragmentation levels, modify the function of the seminiferous epithelium, and ultimately lead to increased apoptosis of spermatogonia and spermatocytes [27,28]

In vitro experiments provided further evidence supporting anti-apoptosis as the antidepressant mechanism of luteolin by showing that luteolin could significantly inhibit apoptosis and reduce NLRP3, caspase-1, and gasdermin D-N levels in hippocampal neurons [79]