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This minimal configuration also explains the efficient transport of -aminolevulinic acid, which serves as a precursor for the endogenous porphyrin accumulation on which photodynamic therapy of tumors is based

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For instance, copper, zinc, and iron, whose excessive concentration is toxic in the body, have been found at significantly elevated concentrations in senile -amyloid plaques and neurofibrillary tangles of AD patient brains compared with healthy controls (Lovell et al., 1998

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