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Strikingly, this form of hepatotoxicity is also associated with cerebral abnormalities such as anxiety, disorientation, sluggish speech, and even loss of consciousness and coma that typically manifest in the form of hepatic encephalopathy 13,14,15,16,17

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Interestingly, one month after the period of APAP intoxication, these mice showed increased glial burden without associated drivers, namely, bloodbrain barrier disruption, cholesterol accumulation, and elevation of inflammatory molecules in the brain and/or periphery

Treatments are spaced 35 weeks apart and are suitable for most skin tones