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showed that the melanocortin-derived tripeptide KPV produced significant anti-inflammatory effects in DSS colitis and CD45RBhi transfer colitis models two of the most commonly used and accepted IBD research paradigms.1 Critically, the anti-inflammatory effect persisted even in animals with a nonfunctional MC1R receptor, confirming that KPV's action does not depend on melanocortin signaling

Vitamin B12 is a complex molecule its chemical name, cobalamin, reflects the presence of the mineral cobalt in the centre of its structure

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and the interplay between the endoplasmic reticulum and actin to drive the contraction of the Drp1 protein to reduce the molecular spacing, leading to the rupture of the OMM and IMM and ultimately triggering mitochondrial fission (Giacomello et al., 2020