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The sinus tarsi is part of your subtalar joint where your ankle bone meets your heel bone

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In the Kupffer cells, the resident macrophages of the liver, betaine serves as an osmolyte and prevents the hyperosmolarity-induced (i) suppression of tumor necrosis factor release and (ii) induction of prostaglandin formation and cyclooxygenase 2 expression, thereby modulating its immune function [14]