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The regulatory focus remains on substances that impair the ability to safely perform job duties

To mitigate this, reduce frequency, consider a lower concentration, and always patch test

The difference is that while cholera enterotoxin causes pathologic changes in intestinal permeability, larazotide improves intestinal permeability and helps to reduce the immune response that occurs when the intestinal membrane is too permeable causing small molecules such as gluten to cross the protective membrane into the blood stream increased membrane permeability or hyperpermeability of the intestinal membrane

This initiative appears to have had a significant impact on Navys eventual leading role in commercializing SBIR-funded technologies through Phase III awards