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4.9 Addressing publication bias and negative outcomes While the majority of studies cited in this review report positive findings regarding the effects of natural compounds in AD models, the potential influence of publication bias must be acknowledged

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Cross-sectional studies showed that Agathobacter and Prevotella_9 abundance correlated positively with eGFR and negatively with microalbuminuria( 3.1.4.2 Translational difficulties between animal models and human studies Approximately 65% of studies cited in this review are based on animal models (primarily db/db mice and STZ-induced diabetic rats), 25% are human cross-sectional studies, and only 10% are human prospective cohort studies

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